Guidelines for acute management of hyperammonemia in the Middle East region.

نویسندگان

  • Majid Alfadhel
  • Fuad Al Mutairi
  • Nawal Makhseed
  • Fatma Al Jasmi
  • Khalid Al-Thihli
  • Emtithal Al-Jishi
  • Moeenaldeen AlSayed
  • Zuhair N Al-Hassnan
  • Fathiya Al-Murshedi
  • Johannes Häberle
  • Tawfeg Ben-Omran
چکیده

BACKGROUND Hyperammonemia is a life-threatening event that can occur at any age. If treated, the early symptoms in all age groups could be reversible. If untreated, hyperammonemia could be toxic and cause irreversible brain damage to the developing brain. OBJECTIVE There are major challenges that worsen the outcome of hyperammonemic individuals in the Middle East. These include: lack of awareness among emergency department physicians about proper management of hyperammonemia, strained communication between physicians at primary, secondary, and tertiary hospitals, and shortage of the medications used in the acute management of hyperammonemia. Therefore, the urge to develop regional guidelines is extremely obvious. METHOD We searched PubMed and Embase databases to include published materials from 2011 to 2014 that were not covered by the European guidelines, which was published in 2012. We followed the process of a Delphi conference and involved one preliminary meeting and two follow-up meetings with email exchanges between the Middle East Hyperammonemia and Urea Cycle Disorders Scientific Group regarding each draft of the manuscript. RESULTS AND DISCUSSION We have developed consensus guidelines based on the highest available level of evidence. The aim of these guidelines is to homogenize and harmonize the treatment protocols used for patients with acute hyperammonemia, and to provide a resource to not only metabolic physicians, but also physicians who may come in contact with individuals with acute hyperammonemia. CONCLUSION These suggested guidelines aim to ease the challenges faced by physicians dealing with acute hyperammonemia in the region. In addition, guidelines have demonstrated useful collaboration between experts in the region, and provides information that will hopefully improve the outcomes of patients with acute hyperammonemia.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ex-ante Impact Study on the Integrated Natural Resources Management in the Middle East and North Africa Region Rangelands Rehabilitation Project in Iran

The purpose of the Integrated Natural Resources Management program in the Middle East and North Africa Region (MENARID) is to bring national investment projects in the field of Integrated Natural Resource Management (INRM). The impact evaluation study tests whether the selected technology has significantly contributed to restore and maintain of the ecosystem functions and productivity, and whet...

متن کامل

Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East

BACKGROUND Management of acute psychotic episodes in schizophrenic patients remains a significant challenge for clinicians. Despite treatment guidelines recommending that second-generation antipsychotics (SGAs) should be used as monotherapy, first-generation antipsychotics, polypharmacy, and lower than recommended doses are frequently administered in clinical practice. Minimal data exist regard...

متن کامل

for New Middle-East in its Interaction with Domination System

Middle-east region has been at the center of attention since a long time ago due to its special geopolitical situation as well as its bountiful energy resources. Domination system's attention to this region is because they try to secure their future energy and guarantee Israel's security against Islamic countries subsequent to Islamic awakening. Therefore natural resources in this region can be...

متن کامل

The Impact of Islamic Awakening on United States' Status in the Middle East Region

In addition to its geographic prominence, the Middle East region possesses an important position in foreign policy of great powers especially the United States. Through the implementation of different policies, these powers seek to secure their interests and interpret historical events into their own interests. Muslim nations' uprising is one of the most important developments in the Middle Eas...

متن کامل

Geo-cultural pattern of Islamic Republic of Iran regarding to Arabic uprising in Middle East (2014-2011)

Since 2011, the region has been a profound socio-economic changes originated from n Tunisia, & spread to Middle Eastern and the former power structures affected. The management and direction to these uprisings is the key question of this paper. The key question, is the foreign policy of the Islamic Republic of Iran how answer to these Middle East public uprisings in the years 2011-2014? <...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Therapeutics and clinical risk management

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2016